Month: May 2018

Neurodegenerative disease researchers have developed a protocol for the consistent transformation of stem cells of fibroblast origin into specific classes of neurons for brain research and drug development. Transient expression of certain transcription factors has been found to endow non-neural cells with neuronal properties. The relationship between reprogramming factors and the transcriptional networks that produce […]

A novel, cell-based gene therapy approach was used to cure hemophilia B in a mouse model of the disease. Hemophilia B, a blood-clotting disorder caused by defects in the gene encoding the protein-clotting factor IX (FIX) is considered to be an appropriate target for gene- and cell-based therapies due to its monogenic nature and broad […]

A new method for maintaining the liver form of the malaria parasite in tissue culture is expected to lay the foundation for next-generation malaria control and elimination.Malaria liver stages represent an ideal therapeutic target with a bottleneck in parasite load and reduced clinical symptoms; however, current in vitro liver stage models for Plasmodium vivax and […]

Zimbabwe Government launched the new cotton hybrids stipulate Quinton’s in partnership with its major investor, Mahyco, an agricultural India based firm. The hybrids are Mahyco C571, Mahyco C567, and Mahyco C608. Despite cotton being one of the vital foreign currency earners in the country, its fabrication had been diminished in the past due to high […]

Alzheimer’s disease researchers have shown that the low molecular weight drug cambinol blocks the formation of exosomes that allow the scatter of insoluble, toxic tau entirety, characteristic neurodegenerative disorder. Tau proteins are components of the cytoskeleton of neurons, but in Alzheimer’s disease, tau proteins become abnormally amend and condense into insoluble from “neurofibrillary tangles” for […]

A team of genome researchers took dominance of the curious nucleotide composition of Plasmodium falciparum DNA to produce mutant strains of the malaria parasite. Pinpoint essential genes and potential drug targets. The extreme adenine-thymine (AT)-bias of the P. falciparum genome has hampered genetic studies through earmark looms such as homologous recombination or CRISPR/Cas9, and only […]

A nanoparticle delivery system was used to transport antibody-based immunotherapeutic drugs in trials synchronize in the cancer cell in vitro cultures and in animal models. Combination immunotherapy has freshly materialized as a sturdy cancer remedy strategy. A promising treatment approach is based on the auxiliary administration of antagonistic antibodies to block checkpoint inhibitor receptors, such […]

Certain genes can determine which people are more at risk of getting the sunburn, and possibly develop skin cancer. In a trawl of the genetics of nearly 180,000 people of European ancestry in Britain, Australia, the Netherlands and the United States, researchers found 20 sunburn genes. Eight of the genes had been associated with skin […]

An adeno-associated viral (AAV) vector was used to deliver a modified version of the CRISPR/Cas9 gene-editing tool to liver cells in a mouse model, which resulted in suppression of the serum enzyme Pcsk9 and reduction of cholesterol levels. It is clear that immune response is an important issue,” said Dr Gersbach. To accommodate the limited […]