Antioxidant In Green Tea Reverses Arthritis Symptoms in Rat Model

Recently investigators at Washington State University (Spokane, USA) worked with cultures of IL-1beta (interleukin 1beta)–stimulated human RA synovial fibroblasts (RASFs) as well as with a rat model of adjuvant-induced arthritis (AIA). They revealed that the green tea compound epigallocatechin-3-gallate (EGCG) was shown to effectively reverse the symptoms of adjuvant-induced arthritis (AIA) in a rat model, which mimics human rheumatoid arthritis (RA). EGCG is the most abundant catechin in tea and is a potent antioxidant that may have therapeutic applications in the treatment of many disorders.  Results published in the February 2016 issue of the journal Arthritis and Rheumatology showed that Western blot analyses of joint homogenates from EGCG-treated rats with AIA showed a significant increase in polyubiquitination, signaling protein transforming growth factor beta–activated kinase 1 (TAK1) phosphorylation, and TNF receptor–associated factor 6 (TRAF6) expression when compared to naive rats. Administration of EGCG for 10 days reversed AIA in rats by reducing TAK1 phosphorylation and polyubiquitination.



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