Conditions in the tumor microenvironment change role of p53

Earlier studies have revealed that in contrast to the situation in CAFs, p53 in normal fibroblasts (NFs) plays a tumor-suppressive role to restrict tumor growth. Cancer researchers have found that changes happen in the tumor microenvironment manipulate the activity of fibroblast p53 protein, causing it to boost rather than restrict cancer growth. This transcriptional rewiring provides p53 a significant contributor to the distinct intrinsic features of CAFs, as well as promoted tumor cell migration and invasion in culture.
The investigators reported in the Proceedings of the National Academy of Sciences of the United States of America that the transcriptional program supported by p53 was altered substantially in CAFs relative to NFs.Cancer cells coexist with noncancerous adjacent cells that constitute the tumor microenvironment and impact tumor growth through diverse mechanisms. The ability of CAFs to boost tumor growth in mice was greatly compromised by depletion of their endogenous p53. Further, co-cultivation of NFs with cancer cells partially rendered their p53-dependent transcript me to be more similar to that of CAFs.
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