A nanoparticle delivery system was used to transport antibody-based immunotherapeutic drugs in trials synchronize in the cancer cell in vitro cultures and in animal models. Combination immunotherapy has freshly materialized as a sturdy cancer remedy strategy. A promising treatment approach is based on the auxiliary administration of antagonistic antibodies to block checkpoint inhibitor receptors, such as anti-programmed cell death‐1 (PD1). Immune checkpoints are regulators of the immune system. These pathways are crucial for self-tolerance, which prevents the immune system from attacking cells arbitrarily.
In this treatment strategy, antibodies targeting checkpoint inhibitor receptors are given together with agonistic antibodies to activate co-stimulatory receptors, such as anti-tumor necrosis factor receptor superfamily member 4 (OX40). OX40’s value as a drug target resides primarily in it being transiently expressed after T-cell receptor engagement. It is only unregulated on the most recently antigen-activated T-cells within inflammatory lesions.
Optimal T‐cell activation is attaining when both immunomodulatory agents simultaneously engage T‐cells and promote synergistic pro-activation signaling. However, standard administration of these therapeutics as free antibodies results in suboptimal T‐cell binding events, with only a subset of the T‐cells binding to both PD1 and OX40
According to Dr Andrew Z. Wang, if we are able to present two different therapeutics at the same time to immune cells to help them fight cancer. Original Link:https://www.biotechdaily.com/drug-discovery/articles/294773464/nanoparticle-delivery-increases-effectiveness-of-anti-cancer-immunotherapy.html