Novel bacterial inhibitor blocks lysozyme activity in model

A team of molecular microbiologists has identified a mechanism by which certain bacteria specifically gram-negative pathogen Neisseria gonorrhoeae – avoid lysozyme demolition. Lysozyme, also known as muramidase or N-acetylmuramide glycanhydrolase is an antimicrobial enzyme prefabricated by animals that form part of the intrinsic immune system. Lysozymes are omnipresent as the first line of immune patronage against microbes in animals. Investigators at Oregon State University (Corvallis, USA) have changed this picture. Although SliC displayed low overall primary concatenation resemblance to the MliC/PliC inhibitors, it was found to have an akin inhibitory mechanism. “The infections very often are silent,

“Said senior author Dr. Aleksandra Sikora, assistant professor of pharmacy at Oregon State University”. Up to 50% of infected women do not have symptoms, but those asymptomatic cases can still lead to some very severe consequences for the patient’s reproductive health, miscarriage or premature delivery. This is the first time an animal model has been used to demonstrate a lysozyme inhibitor’s role in gonorrhea infection. Together, all of our experiments show how important the lysozyme inhibitor is. This is very exciting.”
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