Novel class of enhancer RNAs associate to thriving of Cancers

A recently described class of microRNA has been related to the cancer-promoting activity of the mutated form of p53 protein. MicroRNAs (miRNAs) and short interfering RNAs (siRNA) comprise a class of about 20 nucleotides-long RNA fragments that block gene expression by bind to molecules of messenger RNA in a fashion that block them from transmitting the protein synthesizing command they had collected from the DNA.
MiRNAs resemble siRNAs of the RNA intervention (RNAi) pathway, except miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins, whereas siRNAs derive from longer regions of double-stranded RNA. With their capacity to fine-tune protein expression via sequence-specific interactions, miRNAs help synchronize cell continuation and differentiation. Augmenting the repertoire of “classical” miRNAs, investigators at the University of California, San Diego (USA) identified several thousand enhancer RNAs (eRNAs) that were robustly produced in colon cancer cells in response to chronic immune signaling. Original Link: