Stem cell- establish cultures used for brain disease research

A team of neurological disease researchers used stem cell technology to culture mini-organoids comprising all the major cell types found in the human cerebral cortex – including oligodendrocytes – for brain structure/function research. Oligodendrocytes make myelin, the fatty substance that wraps supports, and insulates nerve cells and connections. Nerve cells that lack myelin cannot convey effectively and may degenerate. Cerebral organoids have been shown to be an accessible system for investigations of cellular composition, interactions, and organization of the brain but have lacked oligodendrocytes. To correct this problem, investigators at Case Western Reserve University School of Medicine (Cleveland, OH, USA) reproducibly produce oligodendrocytes and myelin in “oligocortical spheroids” derived from human pluripotent stem cells.
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