Synthetic fatty acid derivatives present anti-cancer capability

Metabolites fabricate during digestion of omega-3 fatty acids have been found to have anti-cancer properties, and their synthetic derivatives have the potential to be developed into potent chemotherapeutic drugs. Dietary omega-3 fatty acids, such as docosahexaenoic acid (DHA), have been shown to suppress tumor thickening across their conversion to epoxide metabolites. Alternatively, DHA is transformed enzymatically into docosahexaenoyl-ethanolamide (DHEA), an endocannabinoid with anti-proliferative activity. Investigators at the University of Illinois (Champaign-Urbana, USA) had previously narrated a novel class of anti-inflammatory DHEA-epoxide derivative called epoxy docosapentaenoic-ethanolamide (EDP-EA) that contained both ethanolamide and epoxide moieties. To expand those findings they examined the anti-tumorigenic properties of EDP-EAs in an osteosarcoma (OS) mouse model.
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