Version of CRISPR/Cas3 more impactful gene-editing tool
Investigators at Cornell University (Ithaca, NY, USA) delineate that Cas3 from Thermobifida fusca was found to be guided specifically towards Cascade-bound target DNA in the presence of an optimal Protospacer Adjacent Motif (PAM) sequence, and through physical interplay with the CasA component of the Cascade and the non-complementary strand of the ds-DNA substrate. This means […]